EndNote X1 and earlier: Quote from Endnote site

http://www.endnote.com/support/faqs/Install/faq28.asp

You should be able to install and run EndNote, however EndNote X1 and earlier were not designed for 64-bit environments. Therefore, there are some major compatibility and performance issues especially when working with Microsoft Word, as described below. Should you encounter any issues please contact Customer Technical Support using the “Contact us” link at the top of this page, but please be aware that technical support for EndNote may be limited in these environments.

When using the EndNote Cite While You Write tools in Microsoft Word on a PC running Windows XP Professional x64 edition or Vista x64 edition, you may find that there is a noticeable lag when performing certain basic functions in Windows. For example, you may see a delay when switching between open applications or when bringing up the Start menu. We have identified a workaround that prevents this lag.

In Word 2002 XP/2003, select Tools / EndNote / Format Bibliography. In Word 2007, go to the “Add-ins” tab and EndNote / Format Bibliography. With EndNote X1/X2 and Word 2007, hit ALT+3 on your keyboard to bring up the Format Bibliography screen. Select the “Instant Formatting” tab. Select the “Settings” button. Uncheck the two boxes labeled “Scan for temporary citations” and “Check for citation changes.” Click OK, and then OK again.This will prevent the lag when working with the current document.

To prevent it from occurring in future documents… In Word 2002 XP/2003, select Tools / EndNote / Cite While You Write Preferences. In Word 2007, go to the “Add-ins” tab and EndNote / Cite While You Write Preferences. Uncheck the two boxes labeled “Scan for temporary citations” and “Check for citation changes”.

Note that this does not disable Instant Formatting or Cite While You Write. It simply alters the way Instant Formatting works so that the functions that trigger the lag issue are not invoked.

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