About 3.3 billion people – half of the world’s population – are at risk of malaria. In 2010, there were about 219 million malaria cases (with an uncertainty range of 154 million to 289 million) and an estimated 660 000 malaria deaths (with an uncertainty range of 490 000 to 836 000). Increased prevention and control measures have led to a reduction in malaria mortality rates by more than 25% globally since 2000 and by 33% in the WHO African Region. People living in the poorest countries are the most vulnerable to malaria. In 2010, 90% of all malaria deaths occurred in the WHO African Region, mostly among children under five years of age.

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